Contents

Search

diagnostic criteria for Parkinson's disease

Parkinson's disease is a clinical diagnosis. [3] Inclusionary criteria: - clinical criteria alone sufficient [3] - bradykinesia* + at least one of the following: [3] - resting tremor (or with movement) [3] - cogwheel rigidity - postural reflex impairment# - pharmacologic criteria - beneficial response to L-dopa (L-dopa/carbidopa Sinemet) * decrements in speed & amplitude of repetitive movements (dysdiadochokinesia) qualifies as bradykinesia # orthostatic hypotension is exclusionary Exclusionary criteria: 1) parkinsonism due to: a) trauma b) brain tumor c) infection d) cerebrovascular disease e) other known neurologic disease f) drugs or toxins (MPTP) 2) oculomotor palsy 3) cerebellar signs 4) vocal cord paresis 5) orthostatic hypotension 6) pyramidal signs 7) amyotrophy 8) MRI finding of striatal hypointensity Notes: - early falls is an atypical feature [2] - sometimes a clear diagnosis cannot be made for a few years after the disorder presents itself.

Related

Parkinson's disease (paralysis agitans, PD)

General

criteria

References

  1. Cummings JL, The Neuropsychiatry of Alzheimer's Disease and Related Dementias, Martin Dunitz, 2003
  2. Bronstein J, In: Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 29-Oct 2, 2004
  3. Medical Knowledge Self Assessment Program (MKSAP) 17, American College of Physicians, Philadelphia 2015 - Medical Knowledge Self Assessment Program (MKSAP) 19 Board Basics. An Enhancement to MKSAP19. American College of Physicians, Philadelphia 2022